ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4–10 years in advance of clinical symptoms

Authors: D. James Morré, Brandon Hostetler, David J. Taggart, Dorothy M. Morré, A. W. Musk, Bruce W. S. Robinson, and Jenette Creaney

This article describes Liquid Biopsy & Stage Zero Cancer

Stage Zero cancer refers to the presence of disease as detected by liquid biopsy, but prior to the presentation of clinically assessed cancer via PET/CT or MRI scans, or via tissue biopsy.

While using blood tests to detect disease is not particularly new or novel, applying this to detecting cancer prior to its presentation clinically, is relatively new.

Liquid Biopsy refers to using a blood test to gain an insight into the state of cancer, in a similar fashion to extracting a tissue sample and performing a pathological analysis on it would.

Interestingly, the body of research which attempts to tackle the detection of cancer very early on is populated with some fascinating insights.

Specifically, the use of ENOX2 as a biomarker for early disease detection has produced some compelling results, as evidenced here:

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Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue in Chronic Diseases and Cancer

Authors: Garth L. Nicolson, Steven Rosenblatt, Gonzalo Ferreira de Mattos, Robert Settineri, Paul C. Breeding, Rita R. Ellithorpe, and Michael E. Ash

This article describes Phospholipids & Disease Management

While not typical part of a mainstream conversation on daily supplementation, the use of phospholipids in the forms of phosphatidylcholine, phosphatidylserine and phosphatidylinositol, among others, can have a hugely positive impact on both mitochondrial and cell membrane health.

As such, there is also a role for these supplements as part of a disease management strategy when addressing cancer.

Notably, phospholipids are effective at downregulating inflammatory products such as Reactive Oxygen Species and Reactive Nitrogen Species, typical markers of both chronic and acute diseases.

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